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Yue Jin,Zhangqian Liang,Huiqiang Lou.The Emerging Roles of Fox Family Transcription Factors in Chromosome Replication, Organization, and Genome Stability.DOI: 10.3390/cells9010258
发布日期:2020-04-02 浏览次数:  信息来源:澳门威尼人下载APP

The Emerging Roles of Fox Family Transcription Factors in Chromosome Replication, Organization, and Genome Stability

Yue Jin,Zhangqian Liang,Huiqiang Lou


Cells

DOI: 10.3390/cells9010258


Abstract

The forkhead box (Fox) transcription factors (TFs) are widespread from yeast to humans. Their mutations and dysregulation have been linked to a broad spectrum of malignant neoplasias. They are known as critical players in DNA repair, metabolism, cell cycle control, differentiation, and aging. Recent studies, especially those from the simple model eukaryotes, revealed unexpected contributions of Fox TFs in chromosome replication and organization. More importantly, besides functioning as a canonical TF in cell signaling cascades and gene expression, Fox TFs can directly participate in DNA replication and determine the global replication timing program in a transcription-independent mechanism. Yeast Fox TFs preferentially recruit the limiting replication factors to a subset of early origins on chromosome arms. Attributed to their dimerization capability and distinct DNA binding modes, Fkh1 and Fkh2 also promote the origin clustering and assemblage of replication elements (replication factories). They can mediate long-range intrachromosomal and interchromosomal interactions and thus regulate the four-dimensional chromosome organization. The novel aspects of Fox TFs reviewed here expand their roles in maintaining genome integrity and coordinating the multiple essential chromosome events. These will inevitably be translated to our knowledge and new treatment strategies of Fox TF-associated human diseases including cancer.


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